Jay received his PhD in 2006 from MIT, where his thesis focused on fast numerical algorithms for simulation and optimization in drug design and protein engineering. His PhD research was supported in part by a Computational Science Graduate Fellowship (CSGF) award, which is funded by the US Department of Energy. He held postdoctoral fellowships at Argonne National Lab, first in the Mathematics and Computer Science Division and the the Biosciences Division, before becoming a faculty member at Rush University Medical Center (Chicago) in 2009. In 2012, Jay moved to Northeastern University (Boston)'s Department of Electrical and Computer Engineering, and in 2014 he joined Northeastern's Department of Mechanical and Industrial Engineering. In June 2017, Jay joined GlaxoSmithKline as Project Architect for data teams in the Platform Technology and Science Division (now called Medicinal Science and Technology).