DescriptionBringing new medicines to patients can be prohibitively expensive in terms of time, cost, and resources. This leaves many diseases without therapeutic interventions. In addition, new and reemerging diseases are increasing in prevalence across the globe at an alarming rate. The speed and scale of medicine discovery must be increased to effectively meet this challenge. OpeNNdd is a neural network platform bringing together people, machine learning, and supercomputing to solve the challenge of creating medicines. We have developed a novel neural network which quickly and accurately models candidate medicines interacting with a disease target, a metric to delineate its domain of applicability, and a process that communicates neural network results to participants in a readily interpretable way. OpeNNdd leverages the scale of supercomputing, the power and speed of neural networks, and the creativity of people across the globe in an open and collaborative way to protect and improve global health.